Mid-Atlantic Consortium Newsletter Summer 2013

Current Research

Collaborations is dedicated to bringing readers information about the Consortium’s pace-setting research projects.  Some are highlighted in the newsletter’s featured articles.  Listed below are brief descriptions of many other projects of potential interest to patients and families.


phoneLearn further details about the research projects below by calling 1-444-923-3826, listening to the greeting, and then entering the Code Number accompanying the listing of interest.


ADHD

Kennedy Krieger researchers are studying brain structure differences between children with and without ADHD aged 8-12. Children participate in IQ testing, computer tasks, paper/pencil tasks, and an MRI brain scan. PI: Stewart Mostofsky, M.D. Code 203.
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Kennedy Krieger researchers are conducting a new research study of processing speed and memory in children aged 5-9 to further understanding of ADHD. The study involves paper and pencil tasks, computer activities, and Magnetic Resonance Imaging (MRI) of the brain, as well as parent questionnaires and interviews. P.I. E. Mark Mahone, Ph.D. Code 205.
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Kennedy Krieger researchers are studying brain development and learning in boys and girls aged 4-5 to understand early indications of ADHD. The study involves IQ, language and behavioral tests, as well as a Magnetic Resonance Imaging (MRI) scan of the brain. None of these tests are harmful or painful. P.I. :E. Mark Mahone, Ph.D. Code 206.
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Kennedy Krieger researchers are studying how accommodations for children in 6th, 7th and 8th grades with ADHD affects standardized testing. The study involves a 10-minute interview with the parents of affected children and permission to access academic information and children’s educational testing results. P.I.: Alison E. Pritchard, Ph.D. Code 207.
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Autism

Researchers at the Children’s Hospital of Philadelphia are conducting a functional neuroimaging study to further understanding of how autism affects brain development and functioning. Participants include people from six months of age to adulthood with an autism spectrum disorder (ASD). P.I.: Sarah Paterson, Ph.D. Code 102.
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Kennedy Krieger researchers are studying motor differences between children with and without high-functioning autism aged 8-12. Children participate in IQ testing, computer tasks, paper/pencil tasks, and an MRI brain scan. PI: Stewart Mostofsky, M.D. Code 202.
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Children’s National Medical Center investigators are studying the genetic, neurocognitive, behavioral and social factors in children with autism, compared to typically developing peers, aged 6-21. Children participate in behavioral and cognitive testing and MRI scans. PIs: Chandan Vaidya, PhD, and Lauren Kenworthy, Ph.D. Code 301.
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Dyslexia

Researchers at Kennedy Krieger are working on developing a simple, accurate and inexpensive screening test for dyslexia by examining the connection between genes and reading, especially for African American or Hispanic children between the ages of 8 and 15.The study involves taking some school-like tests and collecting saliva for genetic studies. Both children and their parents participate. P.I. E. Mark Mahone, Ph.D. Code 208.
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Epilepsy

Children’s National Medical Center investigators are studying the effects of co-morbidities on the functional anatomy of separate cognitive domains in childhood focal epilepsy. Children with focal epilepsy and typically developing peers aged 8-15 will have detailed cognitive testing and MRI scans. PI: Madison M. Berl, Ph.D. Code 303.
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Rett syndrome

Kennedy Krieger/Johns Hopkins researchers are studying the effects of a placebo-controlled trial of Dextromethorphan in girls aged 2-9 with Rett syndrome (identified by a positive mutation in the MECP2 gene). PI: Sakkubai Naidu, M.D. Code 201.
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Tourette’s syndrome

Kennedy Krieger researchers are studying brain structure differences between children with and without Tourette’s syndrome aged 9-14. Children participate in IQ testing, computer tasks, paper/pencil tasks, and an MRI brain scan. PI: Stewart Mostofsky, M.D. Code 204.
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Other

Researchers at the Children’s Hospital of Philadelphia are conducting a study of Carbaglu, a drug to treat high blood ammonia levels, in people ages 3 and older with propionic acidemia, methylmalonic acidemia, ornithine transcarbamylase deficiency, NAGS deficiency, or CPS deficiency. P.I. Mendel Tuchman, M.D. Code 101.
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Researchers at the Children’s Hospital of Philadelphia are conducting a research study of Parkinsonism and Gaucher disease using state-of-the-art PET imaging to examine brain activity. Adults (18 years of age and older) with Gaucher disease and carriers at risk for Gaucher disease participate. P.I.: Jaya Ganesh, M.D. Code 103.
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